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INSM1 (RBT-INSM1)
INSM1 (RBT-INSM1)
- 中文名称：
- INSM1 (RBT-INSM1)
- 英文名称：
- INSM1 (RBT-INSM1)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59417
- 规格：
- 3 mL (RTU)|0.1 mL (Concentrate)|7 mL (RTU)|0.5 mL (Concentrate)|15 mL (RTU)
- 保存建议：
- Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG
克隆号:[RBT-INSM1]
特异性:N/A
纯度:N/A
形式：Paraffin, Frozen
INSM1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
浓度：N/A
- 说明书：
Insulinoma-associated 1 (INSM1) gene encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain, originally isolated from a human insulinoma-glucagonoma subtraction library.
INSM1 antibody is abundantly expressed in fetal neuroendocrine developmental tissues and expressed in normal adult neuroendocrine (NE) tissues (adrenal medulla, pineal gland, pituitary gland, gastrointestinal enterochromaffin cells, pancreatic islet cells, thyroid C cells) and developing neurons. However there is also a high occurrence of INSM1 found in NE tumors, such as small cell lung cancer (SCLC), pituitary tumors, medullary thyroid carcinoma, Merkel cell carcinoma, olfactory neuroblastoma and pheochromocytoma. It has been reported that INSM1 expresses exclusively in SCLC specimens using immunohistochemistry, and first elucidated that INSM1 regulates the NE differentiation pathway in lung cancer. In addition, it has demonstrated an increased sensitivity and specificity compared to other NE biomarkers (Chromogranin A, Synaptophysin and CD56) in lung cancer specimens. In addition, it's been shown to be involved in NE differentiation in medullary thyroid carcinoma, pheochromocytoma, intestinal NE carcinoma, islet cell tumor, pituitary tumor, and SCLC cell lines.
