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Histone H3S28ph antibody (mAb)(Clone HTA28)
Histone H3S28ph antibody (mAb)(Clone HTA28)
- 中文名称：
- Histone H3S28ph antibody (mAb)(Clone HTA28)
- 英文名称：
- Histone H3S28ph antibody (mAb)(Clone HTA28)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59825
- 规格：
- 0.1 mL|2x0.1 mL|3x0.1 mL|4x0.1 mL|5x0.1 mL
- 保存建议：
- Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20 degree C for up to 2 years. Keep all reagents on ice when not in storage.1ug/ul
- 货期：
- 6-8周
- 来源宿主：
- Rat
- 反应种属：
- Human, Mouse, Rat, Wide Range Predicted
- 应用：
- IHC (Immunohistochemistry), IF (Immunofluorescence)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG2a
克隆号:[HTA28]
特异性:N/A
纯度:Affinity Purified
形式：Purified IgG in 0.1 M Tris-glycine (pH7.4), 150mM NaCl and 0.05% sodium azide. Sodium azide is highly toxic. For your convenience, an ascites version of this antibody is also available.
浓度：1.15ug/ul
- 说明书：
Short Description: Our Histone H3S28ph antibody (mAb)(Clone HTA28) was raised in a Rat host. It has been validated for use in Immunofluorescence and Immunohistochemistry; it has been shown to react with Human, Mouse and Rat samples, but it is predicted that it will react with a wide range of sample types.
Background: Histone H3 is one of the core components of the nucleosome. The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Chromatin is subject to a variety of chemical modifications, including post-translational modifications of the histone proteins and the methylation of cytosine residues in the DNA. Reported histone modifications include acetylation, methylation, phosphorylation, ubiquitylation, glycosylation, ADP-ribosylation, carbonylation and SUMOylation; these modifications play a major role in regulating gene expression. Ser10 phosphorylation and Ser28 phosphorylation in the tail of H3 have very similar kinetics. Both phosphorylations occur early in mitosis when chromosomes begin to condense and during premature chromosome condensation induced in S-phase cells. These phosphorylated serines are excellent mitotic markers. In contrast to Ser10 phosphorylation, Ser28 phosphorylation has never been observed in interphase.
