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p53 antibody (mAb)(Clone DO1)
p53 antibody (mAb)(Clone DO1)
- 中文名称：
- p53 antibody (mAb)(Clone DO1)
- 英文名称：
- p53 antibody (mAb)(Clone DO1)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59878
- 规格：
- 0.01 mg|0.2 mg|2x0.2 mg|3x0.2 mg|4x0.2 mg
- 保存建议：
- Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20 degree C for up to 2 years. Keep all reagents on ice when not in storage.1ug/ul
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human
- 应用：
- WB (Western Blot), IP (Immunoprecipitation), ChIP (Chromatin immunoprecipitation)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG
克隆号:[DO1]
特异性:N/A
纯度:Protein G Chromatography
形式：Purified IgG in 70mM Tris (pH8), 105mM NaCl, 31mM glycine, 0.07mM EDTA, 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.
浓度：1ug/ul
- 说明书：
Short Description: Our p53 antibody (mAb)(Clone DO1) was raised in a Mouse host. It has been validated for use in Chromatin Immunoprecipitation, Immunoprecipitation and Western blot; it has been shown to react with Human samples.
Background: p53 is the most important tumor suppressor in the genome. It is responsive to numerous genotoxic stresses, which activates its transcription factor activity, in turn causing cell-cycle arrest by activating expression of p21 Cip/WAF. Mutant p53 that has lost its DNA-binding function interferes with the activity of native p53 and leads to oncogenic transformation. Alternatively, transformation may be caused by overexpression of Mdm2/Hdm2, a ubiquitin ligase specific for p53, which causes its destabilization. Inactivation of p53 is often coincident with hyperactivation of NFkB (NFkB p50 and NFkB p65), both of which serve to inhibit apoptosis.
