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Proprotein convertase subtilisin/kexin type 9 (PCSK9), NARC1 BLOCKING EPITOPE
Proprotein convertase subtilisin/kexin type 9 (PCSK9), NARC1 BLOCKING EPITOPE
- 中文名称：
- Proprotein convertase subtilisin/kexin type 9 (PCSK9), NARC1 BLOCKING EPITOPE
- 英文名称：
- Proprotein convertase subtilisin/kexin type 9 (PCSK9), NARC1 BLOCKING EPITOPE
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA60508
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human
- 应用：
- ELISA, WB (Western Blot)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Polyclonal
同型:IgG
克隆号:N/A
特异性:N/A
纯度:Ammonium Sulfate Precipitation
形式：Unconjugated
浓度：1mg/ml
- 说明书：
This anitbody is made to an epitope that is reported to block the PCSK9-LDLR (low density lipoprotein receptor) interaction. PCSK9 binds to the EGF-A domain of the LDLR and signals LDLR degradation. Reduced LDLR levels result in decreased LDL (low density lipid) metabolism leading to hypercholesterolemia.
Additionally, PCSK9 may be implicated in the differentiation of cortical neurons and may also play a role in cholesterol homeostasis. Defects in PCSK9 gene are the cause of familial hyperchrolesterolemia 3 (FH3). The protein is thought to play a central role in cholesterol homeostais.
