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Anti-AHI-1 Antibody
Anti-AHI-1 Antibody
- 中文名称：
- Anti-AHI-1 Antibody
- 英文名称：
- Anti-AHI-1 Antibody
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA60782
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|5x0.1 mg|4x0.1 mg
- 保存建议：
- This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Mouse
- 应用：
- IHC (Immunohistochemistry), WB (Western Blot)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG1
克隆号:N/A
特异性:It only specifically reacts with murine Ahi-1.
纯度:Affinity purified
形式：Liquid; PBS, pH 7.4 with 0.02% sodium azide.
浓度：100ug/100ul
- 说明书：
Abelson helper integration site-1 (Ahi-1) is a novel oncogene identified based on its common activation in v-abl and myc-induced murine lymphomas. The murine Ahi-1 gene encodes a unique protein with multiple SH3 binding sites, an SH3 domain and multiple WD40-repeat domains. The conserved human homolog (AHI-1) contains an additional coiled-coil domain in its N-terminal region. Both murine and human Ahi-1/AHI-1 genes encode at least three isoforms and thus this gene is also subject to alternative splicing in normal cells. Expression of Ahi-1/AHI-1 is regulated at multiple stages of hematopoiesis in a highly conserved fashion in mouse and humans. It is highly elevated in certain human lymphoma and leukemia cells, including those from patients with cutaneous T-cell lymphomas (CTCL), BCR-ABL+ chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). AHI-1 is also to be strongly expressed in embryonic hindbrain and forebrain, and AHI-1 may be required for both cerebellar and cortical development in humans. Defects in AHI-1 are the cause of Joubert syndrome, an autosomal recessive brain congenital malformation.
