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Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) Mouse Monoclonal Antibody
Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) Mouse Monoclonal Antibody
- 中文名称：
- Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) Mouse Monoclonal Antibody
- 英文名称：
- Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) Mouse Monoclonal Antibody
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA62703
- 规格：
- 0.02 mg (With BSA & Azide at 0.2mg/mL)|0.1 mg (With BSA & Azide at 0.2mg/mL)|0.1 mg (Without BSA & Azide at 1mg/mL)|5x0.1 mg (With BSA & Azide at 0.2mg/mL)|5x0.1 mg (Without BSA & Azide at 1mg/mL)
- 保存建议：
- Antibody without azide store at -20°C to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human.
Others not known
- 应用：
- IHC (Immunohistochemistry), IF (Immunofluorescence), FCM/FACS (Flow Cytometry)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG1, kappa
克隆号:[1G12]
特异性:N/A
纯度:N/A
形式：200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
浓度：N/A
- 说明书：
Glypican-3 (GPC3) is a glycosylphospatidyl inositol-anchored membrane protein, which may also be found in a secreted form. Anti-GPC3 has been identified as a useful tumor marker for the identification of hepatocellular carcinoma (HCC). Hepatoblastoma, melanoma, testicular germ cell tumor, and Wilm’s tumor . In patients with HCC, GPC3 is overexpressed in neoplastic liver tissue and elevated in serum, but is undetectable in nomarl live, benign liver and the serum of healthy . GPC3 expression is also found to be higher in HCC liver tissue than in cirrhotic liver o liver with focal lesions such as dysplastic nodules and areas of hepatic adenoma (HA) with malignant transformation. In the context of testicular germ cell tumors, GPC3 expression is up regulated in certain histologic subtypes, specifically yolk sac tumors and choriocarcinoma. A high level of GPC3 expression is also found in some types of embryonal tumors, such as Wilm’s tumor and hepatoblastoma, with a low or undetectable expression in normal adjacent tissue. In patients with thyroid cancer, expression of GPC3 is dramatically enhanced in certain types of cancer: 100% in follicular carcinoma and 70% in papillary carcinoma. Expression of GPC3 in follicular carcinoma is significantly higher than that of follicular adenoma. In contrast, GPC3 is not expressed in anaplastic carcinoma.
