
Beta-2 Microglobulin (Renal Failure & Tumor Marker) Mouse Monoclonal Antibody
克隆性:Monoclonal
同型:IgG2b, kappa
克隆号:[B2M/961]
特异性:Recognizes a protein of 12kDa, identified as beta -2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta -2-Microglobulin. beta -2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta -2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.
纯度:N/A
形式:200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
浓度:N/A

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