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Rabbit anti p18INK4C Polyclonal Antibody
Rabbit anti p18INK4C Polyclonal Antibody
- 中文名称：
- Rabbit anti p18INK4C Polyclonal Antibody
- 英文名称：
- Rabbit anti p18INK4C Polyclonal Antibody
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA71306
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C - 8 degree C for three months without detectable loss of activity. Avoid repeated freezing-thawing cycles. Optimal dilutions should be determined by researchers for the specific applications.
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human, Mouse, Rat
- 应用：
- WB (Western Blot), IP (Immunoprecipitation), IHC (Immunohistochemistry), ELISA
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Polyclonal
同型:IgG
克隆号:N/A
特异性:This antibody recognizes p18INK4C protein. It crossreacts to human, mouse and rat. Others are not tested.
纯度:Purified by Epitope Affinity Purification
形式：Supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
浓度：N/A
- 说明书：
Background:
Cyclin-dependent kinases (CDKs) are activated in part by forming complexes with cyclins. For example, CDK4 and CDK6 associate with the D-type cyclins ,md phosphorylate the retinoblastoma protein. This phosphorylation is a necessary event for cells to enter S-phase. The inhibitors of CDK4 (INK4) family include p151NK4B, p16 INK4A, p181NK4C and p19INK4D. p18 has been shown to function as a aploinsufficient tumor suppressor in vivo. All INK4 proteins are composed of 32 amino acid ankyrin motifs and selectively inhibit CDK4/6 activity. Mutational analyses of p18 implicate the third and the aminoterminal portion of the fourth ankyrin repeat in mediating binding to CDK4/6. The interaction of INK4 family members can be a binary complex with CDK4/6 or ternary complex with cyclin D-bound CDK4/6 and ultimately results in the inhibition of cell cycle progression. The gene encoding p15INK4B is often silenced by hypermethylation in acute myeloid leukemia and deleted in acute lymphocytic leukemia.
