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Rabbit anti AXL/UFO (Phospho) Polyclonal Antibody
Rabbit anti AXL/UFO (Phospho) Polyclonal Antibody
- 中文名称：
- Rabbit anti AXL/UFO (Phospho) Polyclonal Antibody
- 英文名称：
- Rabbit anti AXL/UFO (Phospho) Polyclonal Antibody
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA71347
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- The antibodies are stable for 12 months from date of receipt when stored at -20 degree C. The antibodies can be stored at 2 degree C - 8 degree C for one month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human, Mouse, Rat
- 应用：
- WB (Western Blot), IP (Immunoprecipitation), IHC (Immunohistochemistry), FCM/FACS (Flow Cytometry), ELISA
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Polyclonal
同型:IgG
克隆号:N/A
特异性:This antibody recognizes AXL (pY779) with a phosphorylated site at Tyrosine 779. It does not crossreact with non-phosphospecific peptide.
纯度:Purified by site-modified Epitope Affinity Purification.
形式：Supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.
浓度：N/A
- 说明书：
Background: AXL is a member of the Tyr03-Axl-Mer (TAM) receptor tyrosine kinase subfamily. It possesses an extracellu lar domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6), and which is thus regulating many physiological processes including cell survival, cell proliferation , migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation ofAXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of Pl3-kinase subunits PIK3R1 , PIK3R2 and PIK3R3; but also GRB2, PLCG1 , LCK and PTPN11 . Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration , gonadotropin-releasing hormone neuron survival and migration , platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor. AXLlUFO may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types.
