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Rabbit anti GSK-3beta (Paired Ser9), Non-phospho
Rabbit anti GSK-3beta (Paired Ser9), Non-phospho
- 中文名称：
- Rabbit anti GSK-3beta (Paired Ser9), Non-phospho
- 英文名称：
- Rabbit anti GSK-3beta (Paired Ser9), Non-phospho
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA71385
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C-8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human, Mouse, Rat
- 应用：
- IHC (Immunohistochemistry), WB (Western Blot), ELISA
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:N/A
同型:N/A
克隆号:N/A
特异性:This antibody recognizes GSK-3beta (Paired Ser9) without phosphorylated site at Serine 9. It does not cross-react with phosphospecific peptides.
纯度:The Rabbit IgG is purified by site-modified Epitope Affinity Purification.
形式：This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer
浓度：Size: 100 ug/200 ul
- 说明书：
Glycogen Synthase Kinase-3beta (GSK-3beta) is a serine/threonine kinase that affects glycogen metabolism by phosphorylating and down-regulating the activity of muscle glycogen synthase. Growth factor (such as Insulin) binds to its receptor, recruits PKB/AKT kinase to phsphorylate GSK-3beta on Serine 9, which prevents GSK-3beta from phosphorylating glycogen synthase. In contrast, the phosphorylation of tyrosine 216 in the catalytic domain increase this kinase activity to promote cell death under the absence of growth factors. GSK-3beta is also involved in Wnt signaling pathway where it forms a complex with axin, beta-catenin and adenomatous polyposis coli (APC) protein, thus the GSK-3beta inhibitor is considered as a potential approach in Alzheimer's Disease (AD) treatment.
