![beta-Catenin (Tyr-654)[gamma-Catenin (Tyr-644)], phospho-specific Antibody](/skin/notimg.webp)
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beta-Catenin (Tyr-654)[gamma-Catenin (Tyr-644)], phospho-specific Antibody
beta-Catenin (Tyr-654)[gamma-Catenin (Tyr-644)], phospho-specific Antibody
- 中文名称：
- beta-Catenin (Tyr-654)[gamma-Catenin (Tyr-644)], phospho-specific Antibody
- 英文名称：
- beta-Catenin (Tyr-654)[gamma-Catenin (Tyr-644)], phospho-specific Antibody
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA71610
- 规格：
- 0.1 mL|2x0.1 mL|3x0.1 mL|4x0.1 mL|5x0.1 mL
- 保存建议：
- Store at -20 degree C. Stable for 1 year.
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human, Rat, Mouse, Chicken, Fish
- 应用：
- ICC (Immunocytochemistry), ELISA, WB (Western Blot)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Polyclonal
同型:N/A
克隆号:N/A
特异性:This antibody was cross-adsorbed to phospho-beta-Catenin (Tyr-86) peptide before affinity purification using phospho-beta-Catenin (Tyr-654) peptide (without carrier). The antibody detects 84 and 88kDa* proteins corresponding to the molecular mass of gamma-Catenin and beta-Catenin, respectively, on SDS-PAGE immunoblots of A431 cells treated with pervanadate, but does not detect these proteins in control cells.
纯度:N/A
形式：Rabbit polyclonal, affinity-purified antibody is supplied in 100ul phosphate-buffered saline, 50% glycerol, 1mg/ml BSA, and 0.05% sodium azide.
浓度：N/A
- 说明书：
beta-Catenin is a 92kDa protein that binds to the cytoplasmic tail of E-Cadherin. The cadherins, transmembrane adhesion molecules, are found with catenins at adherens junctions. Deletions in the cytoplasmic domain of E-Cadherin eliminate catenin binding and result in a loss of cell adhesion. Tyrosine phosphorylation of beta-Catenin can regulate its interaction with critical components of adherens junctions. Both Fer and Fyn Kinases phosphorylate tyrosine 142 in vitro. Overexpression of these kinases in epithelial cells disrupts interactions between alpha- and beta-Catenins. The phosphorylation of tyrosine 142 may act as a switch from the transcriptional to the adhesive role of beta-Catenin. Src family kinases can also phosphorylate tyrosine 86, 489, and 654 in beta-Catenin. Tyr-654 phosphorylation regulates beta-Catenin binding to E-cadherin, while c-Abl phosphorylation of Tyr-489 decreases beta-Catenin binding to N-Cadherin and leads to nuclear translocation and transcriptional activation.
