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CXCR4 (a.a. 328-338) Antibody
CXCR4 (a.a. 328-338) Antibody
- 中文名称：
- CXCR4 (a.a. 328-338) Antibody
- 英文名称：
- CXCR4 (a.a. 328-338) Antibody
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA71614
- 规格：
- 0.1 mL|2x0.1 mL|3x0.1 mL|4x0.1 mL|5x0.1 mL
- 保存建议：
- Store at 4 degree C, stable for 6 months. For long term storage, aliquot and store at -20 degree C.
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human, Rat, Mouse
- 应用：
- ICC (Immunocytochemistry), ELISA, WB (Western Blot)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Polyclonal
同型:N/A
克隆号:N/A
特异性:The antibody detects bands at 35, 42, 50, and 100kDa* corresponding to various post-translationally modified forms of CXCR4 on SDS-PAGE immunoblots of human Jurkat and PC3 cells. These bands co-migrate with similar bands detected with anti-CXCR4 (Ser-324/Ser-325) and anti-CXCR4 (a.a. 322-329) antibodies.
纯度:N/A
形式：Rabbit polyclonal, affinity-purified antibody is supplied in 100ul phosphate-buffered saline, 1mg/ml BSA, and 0.05% sodium azide.
浓度：N/A
- 说明书：
The chemokine receptor CXCR4 is a widely expressed G protein-coupled receptor required for development, hematopoiesis, organogenesis, and vascularization. In disease, CXCR4 has been implicated in WHIM syndrome, HIV, and cancers. Regulation of CXCR4 function occurs through phosphorylation at multiple sites in the C-terminal region. These sites have been shown to be phosphorylated after CXCL12 stimulation, and involve several kinases, such as PKC and GRK kinases. After CXCL12 stimulation of HEK293 cells, Ser-324 and Ser-325 become phosphorylated by PKC and GRK6, while Ser-330 and Ser-339 are phosphorylated by only GRK6. In human astroglia cells, Ser-324 and Ser-325 are rapidly phosphorylated in endogenous CXCR4, while Ser-330 was phosphorylated with slower kinetics. In addition, arrestin binding to CXCR4 is driven by this phosphorylation of far C-terminal residues. Thus, site-specific phosphorylation of CXCR4 may be regulated by multiple kinases lead to complex regulation of CXCR4 signaling.
