Mitofilin Antibody-Mitofilin Antibody-一抗检测抗体 - 北京博蕾德生物科技有限公司

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: Mitofilin Antibody

Mitofilin Antibody

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中文名称：: Mitofilin Antibody

英文名称：: Mitofilin Antibody

品牌：: AAA Biotech

品牌介绍：: AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。

货号：: AAA71657

规格：: 0.1 mL|2x0.1 mL|3x0.1 mL|4x0.1 mL|5x0.1 mL

保存建议：: Store at -20 degree C. Stable for 1 year.

货期：: 6-8周

来源宿主：: Mouse

反应种属：: Human

应用：: IP (Immunoprecipitation), ICC (Immunocytochemistry), ELISA, WB (Western Blot)

免责声明：: *本产品仅供科研实验使用，不得用于临床诊断。*

其他：: 克隆性:Monoclonal
同型:IgG1
克隆号:[M027]
特异性:Clone M027 detects a 90kDa* band corresponding to the molecular mass of mitofilin on SDS-PAGE immunoblots of native or denatured human PC3, MDA-MB-231, A431, A549, and MeWo cell lysates, as well as human breast, skin, and brain tissues. In addition, mass spectrometry analysis of immunoprecipitates usingmM0271 in human A431 cell lysates confirms this antibody only detects Mitofilin protein. The antibody can be used for multiple applications including ELISA, western blot, immunocytochemistry, and immunoprecipitation.
纯度:Protein G chromatography
形式：Mouse monoclonal antibody purified with protein G chromatography is supplied in 100ul phosphate-buffered saline, 50% glycerol, 1mg/ml BSA, and 0.05% sodium azide.
浓度：N/A

说明书：

Mitofilin is an important organizer of mitochondrial architecture. The mitofilin sequence encodes a polypeptide with a central alpha-helical region with predicted coiled coil domains flanked by globular amino and carboxy termini. There are four isoforms of mitofilin, and 90/91kDa mitofilin forms have been observed in western blots. Mitofilin is located in the inner mitochondrial membrane and interacts with several protein complexes of the outer membrane, thereby generating contact sites between the two membrane systems of mitochondria. These mitofilin-containing hetero-oligomeric protein complexes form the mitochondrial inner membrane organizing system (MINOS). MINOS integrity is required for the structural maintenance of the inner mitochondrial membrane. This mitochondrial region contains cristae membranes that form large tubular invaginations that protrude into the mitochondrial matrix. These cristae membranes contain the enzyme complexes of the oxidative phosphorylation machinery. MINOS deficiency causes loss of crista junction structures and the detachment of cristae from the inner boundary membrane.

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