![Anti-PD-L1 [332M7], Rabbit IgG](/skin/notimg.webp)
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Anti-PD-L1 [332M7], Rabbit IgG
Anti-PD-L1 [332M7], Rabbit IgG
- 中文名称：
- Anti-PD-L1 [332M7], Rabbit IgG
- 英文名称：
- Anti-PD-L1 [332M7], Rabbit IgG
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA72283
- 规格：
- 0.2 mg|2x0.2 mg|3x0.2 mg|4x0.2 mg|5x0.2 mg
- 保存建议：
- Store at 4 degree C for up to 3 months. For longer storage, aliquot and store at -20 degree C.
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human, Mouse, Cynomolgus Monkey
- 应用：
- Blocking, FCM/FACS (Flow Cytometry)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:N/A
同型:Rabbit IgG, Kappa
克隆号:[332M7]
特异性:This antibody strongly binds human and cynomolgus monkey PD-L1 and shows weak binding for mouse PD-L1. PD-L1 is highly expressed in many human tumors.. PD-L1 exerts an immune suppressive signal through binding to PD-1 and B7.1, and tumor expression of PD-L1 can mediate cancer immune evasion. Blocking this pathway, therefore provides a rationale for cancer immunotherapy.
纯度:Protein A affinity purified
形式：PBS with 0.02% Proclin 300.
浓度：1mg/ml
- 说明书：
The binding characterization of this antibody towards human, mouse and cynomolgus monkey PD-L1 was done using flow cytometry. This antibody was shown to block the binding of hPD-1-Fc protein to hPD-L1 expressed on the surface of the HEK-293T cells at a concentration of 10 ug/ml. The mouse version of this antibody was reported to inhibit patient derived melanoma tumor in tumor-bearing mice. There was also found an increase in the gene expression of CD8 and IFN-gamma in tumor samples from mice treated with mouse version of this antibody (US20180346571).
