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Calretinin
Calretinin
- 中文名称：
- Calretinin
- 英文名称：
- Calretinin
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA76734
- 规格：
- 0.1 mL|2x0.1 mL|3x0.1 mL|4x0.1 mL|5x0.1 mL
- 保存建议：
- Antibody can also be aliquotted and stored frozen at -20 degree C in a manual defrost freezer for sixmonths without detectable loss of activity. The antibody can be stored at 2 degree - 8 degree C for 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human, Mouse, Rat
- 应用：
- IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ICC (Immunocytochemistry)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Polyclonal
同型:Rabbit IgG
克隆号:N/A
特异性:N/A
纯度:N/A
形式：Liquid. Supplied as an aliquot of serum plus 5mM NaN3
浓度：N/A
- 说明书：
Calretinin is a member of the large superfamily of cytoplasmic Calcium binding proteins and is expressed in mammalian central nerve system, testis, fallopian tube and pancreas. It contains "EF hand" type Calcium binding motifs and in the brain is localized in certain classes of neurons, the prototype for which is parvalbumin. Calretinin is particularly concentrated in some cerebellar granular cells and their parallel fibers, but is also found in many GABAergic interneurons in the cortex. These GABAergic interneurons in most cases express only one of three related Calcium binding proteins, namely calretinin, calbindin or parvalbumin. As a result these important inhibitory interneurons can be identified and classified based on their content of these three proteins. Each type of neuron as defined in this fashion has distinct electrophysiological and functional properties. The function of calretinin appears to be primarily buffering the Calcium level in cells and affect intracellular Calcium signals. Calretinin deficiency in mice in the mossy cells of the dentate gyrus and granule cells results in abnormal excitability in the cerebellar neuronal network and impairment of long-term potentiation and motor coordination.
The rabbit polyclonal antibody to Calretinin, RA22144, was made against full length recombinant human calretinin expressed in and purified from E coli. The calretinin protein is related in amino acid sequence to calbindin and to a lesser extent parvalbumin, so, for studies of GABAergic interneurons, it is important to verify that antibodies developed against one protein do not cross react with either of the others, which has been done with this antibody.
