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IFN-alpha, Mouse, mAb F18
IFN-alpha, Mouse, mAb F18
- 中文名称：
- IFN-alpha, Mouse, mAb F18
- 英文名称：
- IFN-alpha, Mouse, mAb F18
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA77791
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- Product should be stored at 4 degree C. Under recommended storage conditions, product is stable for one year.
- 货期：
- 6-8周
- 来源宿主：
- Rat
- 反应种属：
- Cross reactant: Human IFN Reactivity: No
Cross reactant: Mouse IFN-Beta Reactivity: No
Cross reactant: Mouse IFN-gamma Reactivity: No
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:Rat IgG1
克隆号:N/A
特异性:N/A
纯度:N/A
形式：1 ml (100 ug/ml) 0.2 um filtered protein G purified antibody solution in PBS, containing 0.1% bovine serum albumin. The endotoxin concentration is < 24 EU/mg, determined with MBS584532 LAL Assay
For unit size 0.5 mg or larger: PBS only
浓度：N/A
- 说明书：
The monoclonal antibody F18 recognizes and neutralizes both natural and recombinant mouse alpha Interferon (IFN-alpha). IFN-alpha is a cytokine that belongs to the type I interferons (IFN-I). IFN-alpha is secreted by many cell types including lymphocytes (NK cells, B-cells and T-cells), macrophages, fibroblasts, endothelial cells, osteoblasts, microglia and others. Interferons stimulate both macrophages and NK cells to elicit an anti-viral response, and are also active against tumors. Although all cells can produce IFN-I, plasmacytoid dendritic cells (pDCs) produce 1,000-fold higher levels than other cell types, and are responsible for systemic IFN-I responses to many viruses. They are coined as the natural IFN-producing cells. However, under deprived pDC condition, other dendritic cells are capable of producing high levels of IFN-I.
Interferons were initially characterized for their ability to 'interfere' with viral replication, slow cell proliferation, and profoundly alter immunity. IFN-alpha has several regulatory roles and diverse biological activities, including control of cellular and humoral immune responses, inflammation, and tumor regression. In addition, IFN-alpha participates in the regulation of various cellular and humoral processes such as the endocrine system modulates behavior, brain activity, temperature, glucose sensitive neurons, feeding pattern and opiate activity.
With the availability of monoclonal antibodies directed against IFN-alpha, it is possible to interpret results obtained from crude materials containing both IFN-alpha and IFNbeta. The difficulties in studying in vitro and in vivo effects of 'type 1'. Interferons arise from the fact that both alpha and beta Interferons are produced in response to the same stimuli and also seem to act via the same receptor. These Interferon activities can only be distinguished from one another by use of specific neutralizing antibodies.
