-
MPO, Mouse, mAb 8F4
MPO, Mouse, mAb 8F4
- 中文名称：
- MPO, Mouse, mAb 8F4
- 英文名称：
- MPO, Mouse, mAb 8F4
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA77797
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- Product should be stored at 4 degree C. Under recommended storage conditions, product is stable for one year.
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Reactivity: Mouse. Cross reactivity: Rat
- 应用：
- IA (Immunoassay), FCM/FACS (Flow Cytometry), Activity Assay
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:Mouse IgG1
克隆号:N/A
特异性:N/A
纯度:N/A
形式：For 0.1 mg: 1 ml (100 µg/ml) 0.2 µm filtered protein G purified biotinylated antibody solution in PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide.
For 0.5 and higher: PBS only (concentration< 0.5mg/ml)
For unit size 0.5 mg or larger
浓度：N/A
- 说明书：
Product Description: The monoclonal antibody 8F4 recognizes mouse myeloperoxidase (MPO). MPO is a glycoprotein produced as a single precursor, which is subsequently cleaved into a alpha and beta chain. In human the biologically active MPO is a 150kDa tetramer composed of 2 glycosylated alfa chains of 59-64 kDa and 2 beta chains of 14 kDa.- MPO is- stored in azurophilic granules of polymorphonuclear leukocytes and is rapidly released into the phagosome and extracellular space during inflammatory conditions.The enzyme catalyzes the conversion of chloride and hydrogen peroxide to hypochlorite, a potent oxidant, which functions in host defense against microorganisms.
Involvement of MPO has been described in several human diseases, such as cardiovascular disease, airway inflammation, lung cancer, Alzheimer's disease and multiple sclerosis. A positive correlation between elevated MPO levels in serum and cardiovascular disease suggest an interesting role for MPO as an marker, making it possible to identify patients at risk for future cardiac events. Furthermore, there are some autoimmune diseases, in which MPO is targeted by antineutrophil cytoplasm antibodies. Studies with MPO-knockout mice have shown an- increased susceptibility to pneumonia following intratracheal infections. Moreover, MPO deficient- mice are more susceptible to experimental autoimmune encephalitis, a T cell-dependent neuronal disease, and have an increased expression of arteriosclerotic plaques compared to wild-type mice.
The anti-mouse MPO monoclonal antibody 8F4 recognizes natural MPO in biological solutions by ELISA,- in frozen tissue sections fixed with acetone and in flow cytometry using a- cell permeabilization method. The antibody 8F4 is cross-reactive- with rat MPO
