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Ficolin-1, Human, mAb 7G1
Ficolin-1, Human, mAb 7G1
- 中文名称：
- Ficolin-1, Human, mAb 7G1
- 英文名称：
- Ficolin-1, Human, mAb 7G1
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA77805
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- Store at 4°C.
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- N/A
- 应用：
- WB (Western Blot), IA (Immunoassay), FCM/FACS (Flow Cytometry)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:N/A
同型:IgG1
克隆号:N/A
特异性:N/A
纯度:Protein G
形式：0.2 um filtered in PBS+0.1%BSA+0.02%NaN3
For unit size 0.5 mg or larger: PBS only (concentration< 0.5mg/ml)
浓度：100 ug/ml
- 说明书：
The monoclonal antibody 7G1 recognizes human M-ficolin, also known as ficolin-1. Ficolins are a family of pattern recognition molecules containing both a collagen-like domain and a fibrinogen-like domain that are capable of activating the complement system, through association with MASPs, on the surface of microorganisms. In human, three Ficolins are known: M-Ficolin, L- Ficolin (Ficolin-2), and H-Ficolin (Ficolin-3). M-Ficolin, is mainly expressed by- monocytes, granulocytes and- lung cells and is present locally in areas of inflammation. However, it was recently also found in serum suggesting that M-Ficolin also has a role in systemic immunity like L- and H-Ficolin. Functional analysis of M-Ficolin has demonstrated that it’s ligand is sialic acid present on bacteria since binding was abolished by prior treatment of the bacteria with sialidase. Furthermore, it was shown that M-ficolin facilitates the uptake of E. coli- by a leukemic monocyte lymphoma cell line, suggesting that it functions as a phagocytic receptor on the surface of circulating monocytes. Low cord blood concentration of M-ficolin has been- associated with higher necrotizing enterocolitis-associated fatality and two identified SNPs in the M-ficolin gene are associated with the development of rheumatoid arthritis. The monoclonal antibody 7G1 is suitable for use in immunoassays and western blotting. -
