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Amyloid-beta (N-term), Human, mAb VU17
Amyloid-beta (N-term), Human, mAb VU17
- 中文名称：
- Amyloid-beta (N-term), Human, mAb VU17
- 英文名称：
- Amyloid-beta (N-term), Human, mAb VU17
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA77809
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- Store at 4 degree C. Under recommended storage conditions, product is stable for at least one year.
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human
- 应用：
- IP (Immunoprecipitation), IA (Immunoassay), IHC (Immunohistochemistry)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG2a
克隆号:[VU17]
特异性:N/A
纯度:N/A
形式：1 ml (100 ug/ml) 0.2 um filtered antibody solution in PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide.
For unit size 0.5 mg or larger: PBS only (concentration< 0.5mg/ml)
浓度：N/A
- 说明书：
Antibody clone VU17, formerly known as alphaVU Abeta 17, recognizes the N-terminus of human amyloid beta (i.e. in: Abeta1-38; Abeta1-39; Abeta1-40; Abeta1-42). Amyloid beta peptides are of key importance in the development of Alzheimer's disease (AD) and are present in CSF. AD affects approximately 1% of the population over the age of 80. The disease is characterized by aggregation of Abeta into oligomers, fibrils and plaques deposition of insoluble and aggregated protein in the brain where its neurotoxic action leads to neuronal cell death. The deposits, also called amyloid plaques, are formed around the neuropil. The exact molecular mechanism is still unclear. Abeta is a proteolytic cleavage product, by APP-cleaving enzyme 1 (BACE1) and beta-secretase complex, of membrane bound amyloid precursor protein (APP). Amyloid is the term used for proteins that are misfolded into a cross beta-sheet structure. Abeta is produced by various cell types and is secreted in the interstitial fluid. There are multiple cleavage sites in Abeta domain leading to various fragments of 36-43 amino acids in length. The main peptide in the CSF terminate at residue 40. CSF contains many Abeta isoforms, of which Abeta40 is approximately 10 times more abundant than Abeta42. Abeta40 levels are unchanged in AD, but there is a change in Ab40:Abeta42 ratio in AD. This ratio has been thought of importance. Assessment of Abeta in brain tissue is essential for identification and is crucial for investigating the molecular mechanisms underlying AD. Antibody VU17 is raised against the N-terminus of Abeta. The antibody detects all forms of Abeta deposits without the need for formic acid pre-treatment on paraffin coupes and can be applied in a double staining strategy, making it suitable for investigating co-localization.
