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CRAMP, Mouse, mAb LF7-BB3
CRAMP, Mouse, mAb LF7-BB3
- 中文名称：
- CRAMP, Mouse, mAb LF7-BB3
- 英文名称：
- CRAMP, Mouse, mAb LF7-BB3
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA77815
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- Product should be stored at 4 degree C. Under recommended storage conditions, product is stable for at least one year.
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Mouse
- 应用：
- IA (Immunoassay), FA (Functional Assay)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:Mouse IgG1
克隆号:[LF7-BB3]
特异性:N/A
纯度:N/A
形式：0.2 ml (100 ug/ml) 0.2 um filtered in PBS+0.1%BSA
浓度：N/A
- 说明书：
The monoclonal antibody LF7-BB3 recognizes the mouse protein Cathelin-Related AntiMicrobial Peptide (Cramp). Cathelicidins are a familiy of antimicrobial proteins predominantly found in the peroxidase-negative granules of neutrophils. the cathelicidins are synthesized as preproteins. Within the neutrophils, they are stored in granules as inactive proforms after removal of the signal peptide. The biologic active domains of the cathelicidins reside in the C-terminus. The C-terminal antimicrobial peptides are activated when cleaved from the proforms of the cathelicidins by serine proteases from azurophilic granules. Cramp (Cathelin-Related Anti-Microbial Peptide) is the mouse analogue of human LL-37 peptide, which is the antibacterial C-terminus of hCAP-18 (human cathelicidin). CRAMP forms an amphipathic alpha-helix similar to other antimicrobial peptides. Cramp is a potent antibiotic against Gram-negative bacteria by inhibiting growth of a variety of bacterial strains and by permeabilizing the inner membrane of E.coli directly. Abundant expression of Cramp is found in myeloid precursors and neutrophils. Cramp represents the first antibiotic peptide found in cells of myeloid lineage in the mouse. Inflammatory cells in the mouse can thus use a non-oxidative mechanism for microbial killing. The monoclonal antibody LF7-BB3 is suitable as a capture and/or detection in an immunoassay (ELISA).
