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LAMP-2, Human, mAb C10
LAMP-2, Human, mAb C10
- 中文名称：
- LAMP-2, Human, mAb C10
- 英文名称：
- LAMP-2, Human, mAb C10
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA77820
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- Product should be stored at 4 degree C. Under recommended storage conditions, product is stable for at least one year.
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human
- 应用：
- IA (Immunoassay), FCM/FACS (Flow Cytometry)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:Mouse IgG2b
克隆号:[C10]
特异性:N/A
纯度:N/A
形式：0.2 ml (100 ug/ml) 0.2 um filtered protein G purified antibody solution in PBS, containing 0.1% bovine serum albumin and 0.02 % sodium azide.
浓度：N/A
- 说明书：
Monoclonal antibody C10 recognizes human lysosome-associated membrane protein-2 (LAMP-2; CD107b). LAMP-2 a heavily glycosylated membrane protein expressed in lysosomes. It is a member of a family of membrane glycoproteins like MAP-1, LIMP2 and DC-LAMP. It is a heavily glycosylated protein of 383 amino acids. LAMP-2 is expressed in a broad panel of tissues like placenta, lung, liver and kidney. Glycosylation is dependent on cell type and activation status. LAMP-2 exists in three splice variants LAMP-2A, LAMP-2B and LAMP-2C. They differ in their sequence in the transmembrane and cytoplasmic domain that effects their function. LAMP-2 is important for control of lysosomal activity and traffic across the lysosomal membranes. Its ability to mediate fusion between autophagosomes and lysosomes makes it important for the process of autophagy. The protein is also involved in cholesterol transport and cytoplasmic antigen MHCII presentation. Normally LAMP-2 is expressed at low levels on the cell surface. The degree of surface expression is dependent on the cell type and state of activation. Genetic deficiency of LAMP-2 causes Danon disease inducing cardiomyopathy and myopathy. Recent studies show also involvement in ANCA-vasculitis.
