-
CRB3 Rat Monoclonal Antibody (14F9)
CRB3 Rat Monoclonal Antibody (14F9)
- 中文名称：
- CRB3 Rat Monoclonal Antibody (14F9)
- 英文名称：
- CRB3 Rat Monoclonal Antibody (14F9)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA77832
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- Lyophilized antibodies can be kept at 4°C for up to 3 months and should be kept at 4°C for up to 3 months and should be kept at -20°C for long-term storage (2 years). To avoid freeze·thaw cycles, reconstituted antibodies should be aliquoted before freezing for long·term (1 year) storage (-80°C) or kept at 4°C for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy.
- 货期：
- 6-8周
- 来源宿主：
- Rat
- 反应种属：
- Human, Mouse
- 应用：
- IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:lgG2c
克隆号:[14F9]
特异性:The antibody recognizes the full length CRB3 protein but not the extra cellular domain of CRB3. Recognize the overexpressed human form and the endogenous form in mouse.
纯度:N/A
形式：Lyophilized protein G purified in PBS pH7.4
浓度：N/A
- 说明书：
CRB3 (Crumbs homologue 3) is an apical transmembrane protein member of the CRB protein family reported to be associated with tight junctions at the apical surface of epithelial cells and to play a role in apical membrane morphogenesis and tight junction regulation. The formation and maintenance of tight junctions is essential for the development of epithelial cell polarity. Two CRB3 isoforms have been described and CRB3 is homologous to the Crumb protein found in Drosophila. CRB3 contains a putative signal peptide in its first 20 amino acids, a putative extracellular site, and a transmembrane domain. The intracellular domain contains a PDZ-binding motif which is involved in the interactions of CRB3 with PARD6A and MPP5. Loss of CRB3 expression in immortal baby mouse kidney (iBMK) cells was reported to render these cells tumorigenic, suggesting an important role for CRB3 function in maintaining epithelial junction formation and apicobasal polarity required for contact-inhibited growth, and to suppress invasion and metastasis.
