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mAb anti-human Raf-1
mAb anti-human Raf-1
- 中文名称：
- mAb anti-human Raf-1
- 英文名称：
- mAb anti-human Raf-1
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA77910
- 规格：
- 0.1 mg|0.5 mg|2x0.5 mg|3x0.5 mg|4x0.5 mg
- 保存建议：
- 储存在-20摄氏度
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human. Others not tested
- 应用：
- WB (Western Blot)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG1,k
克隆号:[410]
特异性:Reactive to Raf-1 N-terminal (1-240 a. a.)
纯度:Protein G affinity purified
形式：Lyophilized from a solution in 0.01M PBS, pH 7.2
浓度：N/A
- 说明书：
Raf-1 is a serine/threonine protein kinase in the mitogen-activated protein kinase (MAPK) pathway. When extracellular signal binds to the G-protein coupled membrane receptor, Ras binds to GTP and phosphorylates Raf. The activated Raf phosphorylates MAPK kinase, which consecutively, activates MAPK. MAPK triggers the transcription of a wide spectrum of genes involved with cell growth and differentiation by activating transcription factors such as C-myc and CREB. MAPK also regulates translation by phosphorylating RSK, a ribosomal protein 6S kinase.
Gene for Raf-1 is located on chromosome 3. The mutations on Raf-1 may relate to some rare but severe diseases such as Noonan syndrome and Leopard syndrome.
