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anti-human CD272 (BTLA)-FITC
anti-human CD272 (BTLA)-FITC
- 中文名称：
- anti-human CD272 (BTLA)-FITC
- 英文名称：
- anti-human CD272 (BTLA)-FITC
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA78171
- 规格：
- 120 Tests|2x120 Tests|3x120 Tests|4x120 Tests|5x120 Tests
- 保存建议：
- Store at 2 - 5 degree C. Do not freeze! Protect from light.
Product should retain activity for at least 12 months after shipping date when stored as recommended.
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human
- 应用：
- ELISA, FCM/FACS (Flow Cytometry)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG1k
克隆号:[ANC5A5]
特异性:N/A
纯度:N/A
形式：50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 5% Glycerol, 0.2% BSA.
浓度：Volume: 0.2ml
- 说明书：
Information: Human CD272 (BTLA, B and T Lymphocyte Attenuator) is a member of the Immunoglobulin superfamily and has sequence homology to PD-1 and CTLA4. It is expressed on T and B lymphocytes and other hemopoetic lineages. Engagement of this molecule by its ligand, CD270(HVEM, a TNF superfamily member) can down regulate activated T and B cell responses. CD272 levels on antigen specific CD8+ T cells have been reported to decrease in viral specific, but not melanoma specific activated lines (1). Polymorphism of the CD272 molecule has been linked to rheumatoid arthritis (3). Antibody from clone ANC5A5 binds to CD272 on the cell surface of human PBMC in Flow cytometry and to recombinant CD272-muIg in EIA. This antibody does not block binding of Biotinylated CD270(HVEM)-muIg to CD272-muIg in EIA, but appears to enhance this interaction. Antibodies ANC6E9 and ANC5A5 each bind a distinct epitope of CD272 and are suitable as a matched pair for EIA using ANC6E9 as capture and Biotinylated ANC5A5 as detector.
