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Polyclonal Antibody to cIAP-2/HIAP-1
Polyclonal Antibody to cIAP-2/HIAP-1
- 中文名称：
- Polyclonal Antibody to cIAP-2/HIAP-1
- 英文名称：
- Polyclonal Antibody to cIAP-2/HIAP-1
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA78332
- 规格：
- 0.05 mL|2x0.05 mL|3x0.05 mL|4x0.05 mL|5x0.05 mL
- 保存建议：
- Store the antibody at 4 degree C, stable for 6 months.
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human
- 应用：
- WB (Western Blot), IHC (Immunohistochemistry), IP (Immunoprecipitation)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Polyclonal
同型:IgG
克隆号:N/A
特异性:N/A
纯度:Serum
形式：50 ul sera
浓度：N/A
- 说明书：
This antibody recognizes cIAP2;which is a 604 amino acid protein belongs to the family of inhibitor of apoptosis proteins (IAP). Resistance towards apoptosis is a hallmark of cancer cells, and overexpression of IAPs can contribute to the development of cancer though inhibiting apoptosis. IAPs suppress mitochondria-dependent and -independent apoptosis by binding to and inhibiting caspases through their BIR domains. In addition to BIR domain, some IAP members also have a RING-type finger motif at their carboxyl-terminal. Smac/DIABLO is a death inducer and functions by inhibiting IAP-caspase interactions, thereby promoting apoptosis. Degradation of cell death inducers like Smac/DIABLO is thought to be a conserved mechanism by which IAPs enhance their anti-apoptotic activity, thereby promoting cell survival. The IAPs, including cIAP2, have widespread tissue protein expression, with expression levels and subcellular localization patterns differing depending on the cell lineage.
