-
Polyclonal Antibody to Mcl-1
Polyclonal Antibody to Mcl-1
- 中文名称：
- Polyclonal Antibody to Mcl-1
- 英文名称：
- Polyclonal Antibody to Mcl-1
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA78345
- 规格：
- 0.05 mL|2x0.05 mL|3x0.05 mL|4x0.05 mL|5x0.05 mL
- 保存建议：
- Store the antibody at 4 degree C, stable for 6 months.
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.
- 货期：
- 6-8周
- 来源宿主：
- Rabbit
- 反应种属：
- Human
- 应用：
- ICC (Immunocytochemistry), IF (Immunofluorescence), IP (Immunoprecipitation), IHC (Immunohistochemistry), WB (Western Blot)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Polyclonal
同型:IgG
克隆号:N/A
特异性:N/A
纯度:Serum
形式：50 ul sera
浓度：N/A
- 说明书：
This antibody recognizes Mcl-1, isoforms 1 and 2. Human Mcl-1 isoform 1 is a 350 amino acid protein. Bcl2 family members can be divided into 3 main subfamilies on the basis of their function and the content of their Bcl2 homology (BH) domains, for example: 1) Prosurvival: Bcl-2, BclXL, BclW, A1, and Mcl-1and 2) Proapoptotic (multidomain): Bax, Bak, and Bok. 3) BH3-only (proapoptotic): Bad, Bcl-XS, Bid, Bik, Bim, Blk, Bmf, Bnip, Noxa, and Puma. The BH domains are important for function as well as for heterodimerization between family members. Typical prosurvival members have all four BH domains (1-4), whereas proapoptotic (multidomain) members have BH1, 2 and 3 domains and BH3-only members have only the BH3 domain. Overall, the relative ratio of prosurvival and proapoptotic proteins determines the suseptibility of a cell to various apoptotic stimuli. Prosurvival proteins are often elevated in diverse cancers and have the potential to confer resistance to both endogenous cell death stimuli and cancer treatments. Alterations in the ratio or levels of Bcl2 proteins have been also associated with nonmalignant diseases including neurodegenerative diseases, autoimmune diseases, AIDs, Down's syndrome, cardiovascular diseases, diabetes, glomerulonephritis, and muscular dystrophy.
