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Monoclonal Antibody to DR4 (Clone: ABM1B11) FITC Conjugated
Monoclonal Antibody to DR4 (Clone: ABM1B11) FITC Conjugated
- 中文名称：
- Monoclonal Antibody to DR4 (Clone: ABM1B11) FITC Conjugated
- 英文名称：
- Monoclonal Antibody to DR4 (Clone: ABM1B11) FITC Conjugated
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA78399
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- Store the antibody at 4 degree C; stable for 6 months.
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human
- 应用：
- FCM/FACS (Flow Cytometry)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG1 Kappa
克隆号:[ABM1B11]
特异性:N/A
纯度:Purified
Protein G Chromatography
形式：100ug in 500ul Tris and 0.05% sodium azide. Sodium azide is highly toxic
浓度：N/A
- 说明书：
Death receptor 4 (DR4) or TRAIL-R1, a member of the tumor necrosis factor receptor superfamily, is a cell surface receptor that triggers the apoptotic machinery upon binding to its ligand tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. DR4 expression is enhanced by DNA damage whether induced by ionizing radiation or by chemotherapeutic agents. On binding DR4, TRAIL induces cell death via caspase-dependent apoptosis. DR4 mediate oligomeric Abeta induction of extrinsic apoptotic pathways in human microvascular cerebral endothelial cells with activation of both caspase-8 and caspase-9. It is considered a promising molecular target for cancer therapy.
