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Monoclonal Antibody to DNMT3a (Clone: ABM13G4) FITC Conjugated
Monoclonal Antibody to DNMT3a (Clone: ABM13G4) FITC Conjugated
- 中文名称：
- Monoclonal Antibody to DNMT3a (Clone: ABM13G4) FITC Conjugated
- 英文名称：
- Monoclonal Antibody to DNMT3a (Clone: ABM13G4) FITC Conjugated
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA78427
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- Store the antibody at 4 degree C, stable for 6 months.
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human
- 应用：
- FCM/FACS (Flow Cytometry)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG1, Kappa
克隆号:[ABM13G4]
特异性:N/A
纯度:Purified
Protein G Chromatography
形式：Purified; 25ug in 125 ul/100ug in 500ul Tris and 0.05% sodium azide is highly toxic
浓度：N/A
- 说明书：
Dnmt3a belongs to the mammalian methyltransferase gene family which is responsible for tissue-specific gene expression. Dnmt3a together with other methyltransferases conducts de novo methylation of cytosine residues in CpG islands by the enzymatic addition of methyl residues from S-adenosyl-L-methionine to the 5-carbon atom of the cytosine ring. Dnmt3a also directs a metabolic program by repressing key genes to enable the coupling of insulin secretion to glucose levels during beta cell maturation. Loss of Dnmt3a in pancreatic beta cells prevents this developmental metabolic reprogramming, resulting in loss of GSIS (Glucose-Stimulated Insulin Secretion)). Dnmt3a overexpression has been found in several cancers including AML (Acute Myeloid Leukemia).
