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Mouse Monoclonal Antibody to Insulin Receptor (Clone: IR-1)
Mouse Monoclonal Antibody to Insulin Receptor (Clone: IR-1)
- 中文名称：
- Mouse Monoclonal Antibody to Insulin Receptor (Clone: IR-1)
- 英文名称：
- Mouse Monoclonal Antibody to Insulin Receptor (Clone: IR-1)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA78499
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- Store at 2 to 8 degree C.
For long-term storage, store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous.
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human
- 应用：
- FCM/FACS (Flow Cytometry)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG1, kappa
克隆号:[IR-1]
特异性:N/A
纯度:Protein G Chromatography
形式：0.5ug/ml of MAb purified by Protein G. Prepared in PBS with 0.05% BSA & 0.05% azide
浓度：N/A
- 说明书：
The insulin receptor (IR) is a heterodimeric protein complex that has an intracellular subunit and an extracellular subunit, which is disulfide-linked to a transmembrane segment. The insulin ligand binds to the IR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to IR induces phosphorylation of intra-cellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. Type 1 diabetes is an auto-immune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells.
