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Hamster Anti-Mouse KLRG1/MAFA-LE/AF
Hamster Anti-Mouse KLRG1/MAFA-LE/AF
- 中文名称：
- Hamster Anti-Mouse KLRG1/MAFA-LE/AF
- 英文名称：
- Hamster Anti-Mouse KLRG1/MAFA-LE/AF
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA78683
- 规格：
- 0.5 mg|2x0.5 mg|3x0.5 mg|4x0.5 mg|5x0.5 mg
- 保存建议：
- Store at 2-8°C or aliquot into smaller volumes and store at -20°C. Avoid multiple freeze / thaw cycles.
- 货期：
- 6-8周
- 来源宿主：
- Hamster
- 反应种属：
- Mouse
- 应用：
- IP (Immunoprecipitation), FCM/FACS (Flow Cytometry)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:Hamster (Syrian) IgG2
克隆号:[2F1]
特异性:Mouse/Human KLRG1; Mr 30-38 kDa
纯度:N/A
形式：Supplied as 0.5 mg purified immunoglobulin in 1.0 mL of PBS.
浓度：N/A
- 说明书：
The monoclonal antibody 2F1 reacts with mouse killer cell lectin-like receptor G1 (KLRG1; formerly known as mouse MAFA or 2F1-Ag), a homodimeric member of the lectin-like type 2 transmembrane receptor family that contain characteristic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic domains.1, 2 These ITIMs interact with the SH2 domains of protein phosphatases such as SHP-1.3, 4 The 2F1 antibody stains 30-60% of NK1.1+CD3- splenocytes, and a small fraction of T cells in all mouse strains tested (C57BL/6, BALB/c, 129/J, C3H.SW, AKR/J, SJL).1, 5 Cell surface expression of KLRG1 is up-regulated by expression of MHC class I molecules. The effect of MHC class I expression is indirect, and can be mediated by interactions with class I-specific Ly49 inhibitory receptors.
