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Rat Anti-Mouse CD117/c-kit-FITC
Rat Anti-Mouse CD117/c-kit-FITC
- 中文名称：
- Rat Anti-Mouse CD117/c-kit-FITC
- 英文名称：
- Rat Anti-Mouse CD117/c-kit-FITC
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA78687
- 规格：
- 0.5 mg|2x0.5 mg|3x0.5 mg|4x0.5 mg|5x0.5 mg
- 保存建议：
- Store at 2-8°C.
- 货期：
- 6-8周
- 来源宿主：
- Rat
- 反应种属：
- Mouse
- 应用：
- FCM/FACS (Flow Cytometry)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:Rat (Wistar) IgG2b κ
克隆号:[2B8]
特异性:Mouse CD117; Mr 150 kDa
纯度:N/A
形式：The fluorescein (FITC) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3.
浓度：0.05 mg/ml
- 说明书：
Description: The CD117 (c-Kit) antigen is the cell-surface receptor for stem cell factor (SCF). Together these molecules constitute a ligand/receptor pair which functions to maintain normal hematopoiesis in the adult. Signaling through SCF/c-Kit has an important role in stimulating myeloid and erythroid production of primitive hematopoietic progenitor cells. A variety of cytokines act synergistically with SCF to stimulate proliferation and differentiation of bone marrow progenitor cells. For example, SCF plus IL-7 can stimulate the combined myeloid and B cell differentiation of uncommitted hematopoietic progenitor cells. SCF/c-Kit also participates in erythropoiesis in both the bone marrow and spleen. Loss-of-function mutations for SCF/c-Kit lead to a variety of pleiotropic developmental defects while gain-of-function mutations can lead to constitutive activation of the kit receptor and links to cancer. Examples of the former are mast cell deficiency and severe macrocytic anemia while the latter mutation has been identified in mastocytomas.
