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mouse anti-Human MFGE8 monoclonal Antibody
mouse anti-Human MFGE8 monoclonal Antibody
- 中文名称：
- mouse anti-Human MFGE8 monoclonal Antibody
- 英文名称：
- mouse anti-Human MFGE8 monoclonal Antibody
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA81754
- 规格：
- 0.05 mg|0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg
- 保存建议：
- 交付时在4摄氏度下装运，并在-20摄氏度或-80摄氏度下储存。避免重复冷冻。
- 货期：
- 6-8周
- 来源宿主：
- Mouse
- 反应种属：
- Human. Other species are not tested. Please decide the specificity by homology
- 应用：
- IHC (Immunohistochemistry), ELISA
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 其他：
克隆性:Monoclonal
同型:IgG2b
克隆号:N/A
特异性:Specific for MFGE8 native and denatured forms
纯度:>95%, Protein G Purified
形式：N/A
浓度：N/A
- 说明书：
Human MFGE8(milk fat globule-EGF factor 8;also lactadherin, breast epithelial antigen BA46, and medin) is a 46 kDa, secreted, monomeric glycoprotein that is associated with the human milk fat globule (HMFG) membrane.It is expressed by mammary epithelial cell surfaces, artery media, and in several carcinomas.Human MGFE8 is synthesized as a 387 amino acid (aa) precursor that contains a 23 aa signal sequence and a 364 aa mature region. The mature molecule contains four Nlinked glycosylation sites, an aminoterminal EGF like domain, plus C1 and C2 Iglike domains which are related to discoidin I and homologous to those of human coagulation factors V and VIII. Within the EGF like domain is an ArgGlyAsp(RGD) sequence, which is strategically placed in a hairpin loop between two antiparallel beta strands. In this way, the EGFlike domain serves as a scaffold for the RGD sequence, which is proposed to promote cell adhesion by binding cellsurface integrin receptors, such as ??v??3. Human MFGE8 shares 59%, 58%, 56%, and 52% aa sequence identity with porcine, bovine, rat, and mouse MFGE8,respectively. Functionally, MFGE8 in milk is reported to block rotavirus infection. MFGE8 expression by macrophages promotes the phagocytosis of apoptotic thymocytes by forming a bridge between phosphatidylserine on apoptotic cells, and ??v??3 integrin on phagocytes. The MFGE8 expression by macrophages controls the accumulation of apoptotic membrane fragments in atherosclerotic plaques and substantially limits lesion development.
