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Human Integrin alpha 2b beta 3 Heterodimer Protein (I874S, DYKDDDDK & His Tag)
Human Integrin alpha 2b beta 3 Heterodimer Protein (I874S, DYKDDDDK & His Tag)
- 中文名称：
- Human Integrin alpha 2b beta 3 Heterodimer Protein (I874S, DYKDDDDK & His Tag)
- 英文名称：
- Human Integrin alpha 2b beta 3 Heterodimer Protein (I874S, DYKDDDDK & His Tag)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA259282
- 规格：
- 0.1 mg|1 mg|2x1 mg|3x1 mg|4x1 mg
- 保存建议：
- Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
- 货期：
- 6-8周
- 纯度：
- >= 90% as determined by SDS-PAGE.
- 产品形式：
- Lyophilized from sterile PBS, pH 7.4.
Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Integrin alpha 2b beta 3 (also GPIIbIIIa) is a key platelet integrin, a noncovalent heterodimer of type I transmembrane subunits alpha 2b/CD41 and beta3/CD61. Capable of binding fibrinogen in its active state, its alpha and beta subunits each comprise a ligand-binding extracellular domain, a single-pass transmembrane helix, and a cytoplasmic tail with binding sites for intracellular proteins. Upon agonist stimulation, alphaIIbbeta3 accepts its extended-open (activated) conformation, increasing its matrix protein RGD motif ligand affinity, subsequently facilitating platelet spreading, platelet aggregation, and thrombus formation. Deficiencies lead to lifelong bleeding diathesis as seen in Glanzmann thrombasthenia. alphaIIbbeta3-targeting therapeutic antibodies can inhibit thrombi formation in patients with acute coronary syndrome, and potentially inhibit tumor angiogenesis and metastasis by blocking interaction of platelet alphaIIbbeta3 with tumor cells.
