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Recombinant Human Cadherin-11 Protein (His Tag), HPLC-verified
Recombinant Human Cadherin-11 Protein (His Tag), HPLC-verified
- 中文名称：
- Recombinant Human Cadherin-11 Protein (His Tag), HPLC-verified
- 英文名称：
- Recombinant Human Cadherin-11 Protein (His Tag), HPLC-verified
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA259283
- 规格：
- 0.1 mg|1 mg|2x1 mg|3x1 mg|4x1 mg
- 保存建议：
- Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
- 货期：
- 6-8周
- 纯度：
- >= 90% as determined by SDS-PAGE. >= 90% as determined by SEC-HPLC.
- 产品形式：
- Lyophilized from sterile 50mM Tris, 100mM NaCl, 3mM Cacl2, 10% Trehalose, 0.02% Tween20, pH 8.0. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
A mesenchymal marker, Cadherin-11's (CDH11) gene is situated on chromosome 16q22.1. CDH11 is a type II atypical cadherin, an integral membrane protein that mediates calcium-dependent, cell-cell homophilic interactions. Defined by a large extracellular N-domain, a single membrane-spanning domain, a small C-cytoplasmic domain, and the lack of an HAV cell adhesion recognition sequence, CDH11 expression is increased in fibrotic diseases such as systemic sclerosis, as well as in chronic inflammatory arthritis. CDH11 leads to promoter methylation inactivation, which can induce cancer cell apoptosis and suppress invasion through Wnt/beta-catenin, AKT/Rho A, and NF-kappaB signaling pathways. CDH11 mRNA and protein was expressed in most invasive breast cancer cell lines tested but not in non-invasive cell lines, suggesting that CDH11 may be a marker for aggressive, invasive tumor subsets.
