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Recombinant SARS-CoV-2 (2019-nCoV) NSP1
Recombinant SARS-CoV-2 (2019-nCoV) NSP1
- 中文名称：
- Recombinant SARS-CoV-2 (2019-nCoV) NSP1
- 英文名称：
- Recombinant SARS-CoV-2 (2019-nCoV) NSP1
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA41020
- 规格：
- 0.05 mg|0.1 mg|1 mg|2x1 mg|3x1 mg
- 保存建议：
- Store at -20 to -80°C for twelve months from the date of receipt.
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
- 货期：
- 6-8周
- 纯度：
- >90% as determined by SDS-PAGE
- 产品形式：
- Lyophilized. Supplied as solution form in PBS, pH7.5
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Recombinant SARS-CoV-2 NSP1 is produced by E.coli expression system and the target gene encoding Met1-Gly180 is expressed with N-His Tag
Background
The Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV) is an enveloped, positive-stranded RNA viruses that can cause a severe respiratory disease. Its genome consists of a ?30 kb linear, non-segmented, capped, polycistronic, polyadenylated RNA molecule, the first two-third of which is directly translated into two large polyproteins. These two polypeptides are processed into 16 non-structural proteins (nsps), forming the replicase complex, which is active in the cytoplasm in close association with cellular membranes. Nsp1 was proved to be able to suppress host gene expression by promoting host mRNA degradation and was involved in cellular chemokine deregulation. This virus evades the host innate immune response in part through the expression of its non-structural protein (nsp) 1, which inhibits both host gene expression and virus- and interferon (IFN)-dependent signaling. Thus, nsp1 is a promising target for drugs, as inhibition of nsp1 would make SARS-CoV more susceptible to the host antiviral defenses.
