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Recombinant Human Thyroid Peroxidase (TPO)
Recombinant Human Thyroid Peroxidase (TPO)
- 中文名称：
- Recombinant Human Thyroid Peroxidase (TPO)
- 英文名称：
- Recombinant Human Thyroid Peroxidase (TPO)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA47958
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- Store at 20 degree C in lyophilized form. After reconstitution, store at -70 degree C. Avoid repeated freezing and thawing.
- 货期：
- 6-8周
- 纯度：
- Greater than 95% as determined by SDS-PAGE. Identity confirmed by MALDI mass spectrometry.
- 产品形式：
- Lyophilized from 20mM Tris-HCl, pH 8.0, 250mM NaCl, 0.1mM KI, 5% D-mannitol. Reconstitute with sterile deionized H2O.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Thyroid peroxidase (TPO) is an integral apical membrane glycoprotein of thyroid follicular cells and plays a key role in thyroid hormone biosynthesis. It is a homodimer comprised of two identical subunits of approx. 100kDa. TPO is one of the main autoantigenic targets in autoimmune thyroid disease of humans. Anti-TPO autoantibodies are present in 90% of cases of Hashimoto's thyroiditis and 75% of cases of Graves' disease.
Recombinant human TPO produced in insect cells corresponds to aa 19-846 (calculated molecular weight approx. 92kDa) of the soluble extracellular domain of human TPO. It does not contain any tags. It is purified by specific monoclonal antibody-based affinityand ion exchange chromato-graphic methods. In SDS-PAGE, two bands in the region of 100-110kDa are observed due to differential glycosyl- ation of the protein. Immunoreactivity of rhuTPO is confirmed by ELISA with patient serum samples containing anti-TPO autoantibodies.
