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Recombinant human TMIGD2/CD28H protein
Recombinant human TMIGD2/CD28H protein
- 中文名称：
- Recombinant human TMIGD2/CD28H protein
- 英文名称：
- Recombinant human TMIGD2/CD28H protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA48995
- 规格：
- 0.01 mg|0.02 mg|0.05 mg|0.1 mg|0.25 mg
- 保存建议：
- Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
- 货期：
- 6-8周
- 纯度：
- 95% by SDS-PAGE
- 产品形式：
- Liquid in. Phosphate-Buffered Saline (pH7.4) containing 10% glycerol
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
TMIGD2, also known as IGPR-1, is a member of the Immunoglobulin family. This protein shares approximately 10% amino acid sequence identity with CD28, CTLA-4, ICOS, and PD-1. The immunoglobulin domain of TMIGD2 was predicted to be Ig V fold and was found to be highly similar to the Ig domain of myelin-associated glycoprotein. It plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, co-stimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. It is constitutively expressed on naive T and NK cells. Similar to the interaction of B7 with CD28, the interaction of TMIGD2 with B7-H7 activates the Akt-dependent signaling cascade and promotes the proliferation and activation of newly generated peripheral effector and memory T cells. Also, it interacts with multiple cytoskeletal proteins. Recombinant human TMIGD2, fused to hIgG-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
