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Recombinant mouse VEGFR1/Flt-1 protein
Recombinant mouse VEGFR1/Flt-1 protein
- 中文名称：
- Recombinant mouse VEGFR1/Flt-1 protein
- 英文名称：
- Recombinant mouse VEGFR1/Flt-1 protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA49007
- 规格：
- 0.01 mg|0.02 mg|0.05 mg|0.1 mg|0.25 mg
- 保存建议：
- Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
- 货期：
- 6-8周
- 纯度：
- > 85% by SDS-PAGE
- 产品形式：
- Liquid in. Phosphate-Buffered Saline (pH7.4) containing 10% glycerol
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
VEGFR1 (Vascular Endothelial Growth Factor Receptor 1), also known as FLT-1 (Fms-like Tyrosine Kinase 1), belongs to the class III subfamily of receptor tyrosine kinases. While VEGFR1, VEGFR2, and VEGFR3 are mainly expressed on endothelial cells, VEGFR1 is uniquely expressed on macrophages and primarily plays inhibitory roles. Inhibitors of VEGFR are used in cancer treatment. VEGFR1 acts as a cell-surface receptor for VEGFA, VEGFB, and PGF, playing essential roles in the development of embryonic vasculature, regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. VEGFR1 binds VEGF with higher affinity than VEGFR2 but exhibits weaker kinase activity. The VEGF-kinase ligand/receptor signaling system is crucial for vascular development and the regulation of vascular permeability. Recombinant mouse VEGFR1/Flt-1, fused to hIgG-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
