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Recombinant SIRT2 (50-356) protein
Recombinant SIRT2 (50-356) protein
- 中文名称：
- Recombinant SIRT2 (50-356) protein
- 英文名称：
- Recombinant SIRT2 (50-356) protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59736
- 规格：
- 0.1 mg|1 mg|2x1 mg|3x1 mg|4x1 mg
- 保存建议：
- Recombinant proteins in solution are temperature sensitive and must be stored at -80 degree C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Shipping Temp: Dry Ice
- 货期：
- 6-8周
- 纯度：
- Recombinant SIRT2 (50-356) protein that includes amino acids 50-356 of human SIRT2 protein (accession number NM_012237.3) was expressed in E Coli and contains an N-terminal GST-Tag with a molecular weight of 66.5 kDa.The purity ofThe protein is >= 85% by
- 产品形式：
- Recombinant SIRT2 (50-356) protein is supplied in 25mM Tris pH8.0, 150mM NaCl, 5% glycerol.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Short Description: Recombinant SIRT2 (50-356) protein includes amino acids 50-356 of human SIRT2 protein (accession number NM_012237.3); it was expressed in E Coli and contains an N-terminal GST-Tag with a molecular weight of 66.5 kDa. The purity of the protein is >= 85% by SDS-PAGE. It is suitable for histone deacetylase assays and use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.
Background: SIRT2 (Sirtuin 2) is a member of the SIR2/Sirtuin family of NAD+-dependant deacetylase enzymes. It has multiple targets for deacetylation, including tubulin, p53, HOXA10, FOXO3A, P300 and FOXO1. SIRT2 suppresses adipogenesis by deacetylating FOXO1, promoting the binding of FOXO1 to PPARg and subsequent repression of PPARg mediated transcriptional activation. Similar to SIRT1, SIRT2 also deacetylates histone H4 at lysine 16. SIRT2 is present in the cytoplasm during most of the cell cycle except in the G2/M transition and in mitosis, where it is found in the nucleus, in contact with chromatin, and is required for exit from mitosis.
