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Recombinant SUV39H1 (82-412) protein
Recombinant SUV39H1 (82-412) protein
- 中文名称：
- Recombinant SUV39H1 (82-412) protein
- 英文名称：
- Recombinant SUV39H1 (82-412) protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA60109
- 规格：
- 0.02 mg|2x0.02 mg|3x0.02 mg|4x0.02 mg|5x0.02 mg
- 保存建议：
- Recombinant proteins in solution are temperature sensitive and must be stored at -80 degree C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Shipping Temp: Dry Ice
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant SUV39H1 (82-412) protein is supplied in 25mM Tris pH8.0, 300mM NaCl, 10% glycerol, and 0.5mM TCEP.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Short Description: Recombinant SUV39H1 (82-412) protein corresponding to amino acids 82-412 of SUV39H1 protein (accession number NP_003164.1) was expressed in E Coli and contains an N-terminal GST-Tag with a molecular weight of 64.6 kDa. Recombinant SUV39H1 (82-412) protein contains the SET domain of SUV39H1 that is responsible for methyltransferase activity. It is suitable for use in histone methyltransferase assays as well as in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.
Background: SUV39H1 (Suppressor Of Variegation 3-9 Homolog 1, also known as KMT1A) is a histone methyltransferase that specifically trimethylates Lys-9 of histone H3, which results in transcriptional gene silencing. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. SUV39H1 and SUV39H2 can regulate the telomere length in mammalian cell. Histone H3 Lys-9 trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. H3K9me3 plays an important role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3K9me3 is also required to direct DNA methylation at pericentric repeats.
