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Recombinant SUV420H1 (2-387) protein
Recombinant SUV420H1 (2-387) protein
- 中文名称：
- Recombinant SUV420H1 (2-387) protein
- 英文名称：
- Recombinant SUV420H1 (2-387) protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA60110
- 规格：
- 0.05 mg|1 mg|2x1 mg|3x1 mg|4x1 mg
- 保存建议：
- Recombinant proteins in solution are temperature sensitive and must be stored at -80 degree C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Shipping Temp: Dry Ice
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant SUV420H1 (2-387) protein is supplied at a concentration of 1.2ug/ul in 25mM Tris pH8.0, 300mM NaCl, 5% glycerol.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Short Description: Recombinant SUV420H1 (2-387) protein corresponding to amino acids 2-387 of SUV420H1 protein (accession number NP_060105.3) was expressed in E Coli and contains an N-terminal GST-Tag with a molecular weight of 71.1 kDa. Recombinant SUV420H1 (2-387) protein contains the SET domain of SUV420H1 that is responsible for methyltransferase activity. It is suitable for use in histone methyltransferase assays as well as in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.
Background: SUV420H1 (Suppressor Of Variegation 4-20 Homolog 1, also known as KMT5B) is a histone methyltransferase that specifically trimethylates nucleosomal histone H4 on lysine 20 (H4K20). H4K20me3 is a histone marker that represents epigenetic transcriptional repression. SUV420H1 mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins. It plays a role in myogenesis by regulating the expression of target genes, such as EID3.
