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Recombinant NEK2 protein
Recombinant NEK2 protein
- 中文名称：
- Recombinant NEK2 protein
- 英文名称：
- Recombinant NEK2 protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA60326
- 规格：
- 0.02 mg|2x0.02 mg|3x0.02 mg|4x0.02 mg|5x0.02 mg
- 保存建议：
- Recombinant proteins in solution are temperature sensitive and must be stored at -80 degree C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
- 货期：
- 6-8周
- 纯度：
- >=50%
- 产品形式：
- Recombinant NEK2 protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10% glycerol, 0.04% Triton X-100, 0.5 mM TCEP.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
NEK2 (NIMA Related Kinase 2) is a protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. NEK2 regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes and regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. NEK2 is involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1 and plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. It is also essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis.
