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Sphingosine-1-Phosphate Receptor 3 (S1PR3) ACTOne Stable Cell Line, HEK293
Sphingosine-1-Phosphate Receptor 3 (S1PR3) ACTOne Stable Cell Line, HEK293
- 中文名称：
- Sphingosine-1-Phosphate Receptor 3 (S1PR3) ACTOne Stable Cell Line, HEK293
- 英文名称：
- Sphingosine-1-Phosphate Receptor 3 (S1PR3) ACTOne Stable Cell Line, HEK293
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA62096
- 规格：
- INQUIRE
- 保存建议：
- Remove the frozen cells from the dry ice packaging and immediately place the cells at a temperature below -130 degree C, preferably in liquid nitrogen vapor, until ready for use.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- N/A
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Introduction: Introduction: S1PR3 is a G-protein-coupled receptor which binds the bioactive signaling molecule sphingosine 1-phosphate (S1P).S1PR3 belongs to a sphingosine-1-phosphate receptor subfamily comprising five members (S1PR3-5). They areexpressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity, although they are found attheir highest density on leuk degree Cytes. S1PR3 has been identified as a functional receptor for sphingosine 1-phosphate andlikely contributes to the regulation of angiogenesis and vascular endothelial cell function.
Description: Human S1PR3 ACTOneTM is a HEK-293 CNG cell line that expresses recombinant human S1PR3. HEK-293 CNG cellsexpress a modified CNG (Cyclic Nucleotide Gated) channel that opens in response to elevated intracellular cAMP levelsand consequently result in ion flux (often detectable by calcium-responsive dye) and cell membranedepolarization which can be easily measured with fluorescent Membrane Potential Dye. The assayallows both end-point and kinetic measurement of intracellular cAMP changes with a FDSS, FLIPR, or a fluorescencemicroplate reader.
This cell line is a HEK-293-CNG cell line that expresses a recombinant human S1PR3. HEK-293-CNG cells express a modified CNG (Cyclic Nucleotide Gated) channel that opens in response to elevated intracellular cAMP levels and consequently result in ion flux and cell membrane depolarization.
