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SARS-CoV-2 Pseudoviral Particles, South Africa Variant
SARS-CoV-2 Pseudoviral Particles, South Africa Variant
- 中文名称：
- SARS-CoV-2 Pseudoviral Particles, South Africa Variant
- 英文名称：
- SARS-CoV-2 Pseudoviral Particles, South Africa Variant
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA62223
- 规格：
- 5 mL|2x5 mL|3x5 mL|4x5 mL|5x5 mL
- 保存建议：
- Upon receiving this item, store at -70°C right away. Thaw each vial immediately before use (Do not aliquot and refreeze). Shelf Life: Six months from the date of shipping when stored at -70°C.
Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Shipping Note: Product is available for shipment in the United States, Canada and European countries. Please inquire for shipment to other countries.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- 10 ml (2 tubes, 5 mL/tube), for 2 multi-well plates
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
SARS-CoV-2 Pseudoviral Particles, replication-deficient MLV pseudotyped with the SARS-CoV-2 spike protein (the South Africa variant B.1.351).
The SARS-CoV-2 Pseudoviral Particles are replication-deficient Maloneymurine leukemia virus (MLV) pseudotyped with the SARS-CoV-2 spike protein of the South Africa variant B.1.351 (a.k.a. 20H/501Y.V2, formerly 20C/501Y.V2) (GISAID sequence accession number: EPI_ISL_736980).
It has been known that SARS coronavirus 2 (SARS-CoV-2) uses human ACE2 as entry receptor and human proteases as entry activators. The virus surface spike protein (S) mediates SARS-CoV-2 entry into cells. To fulfill its function, SARS-CoV-2 spike binds to its human ACE2 (hACE2) receptor through its receptor-binding domain (RBD) and is proteolytically activated by human proteases.
Our SARS-CoV-2-SA Pseudoviral Particles are replication-deficient MLV pseudotyped with the SARS-CoV-2 spike protein of the South Africa variant B.1.351 (a.k.a. 20H/501Y.V2, formerly 20C/501Y.V2) (GISAID sequence accession number: EPI_ISL_736980). They also contain the ORF for firefly luciferase as a reporter. They establish a pseudovirus entry assay for SARS-CoV-2 as the spike protein mediated cell entry can be conveniently measured via luciferase reporter activity. This pseudovirus assay isolates the SARS-CoV-2 viral entry from other steps of the viral infection cycle.
