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Arp2/3 Complex
Arp2/3 Complex
- 中文名称：
- Arp2/3 Complex
- 英文名称：
- Arp2/3 Complex
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA71555
- 规格：
- 1 Kit|2x1 Kit|3x1 Kit|4x1 Kit|5x1 Kit
- 保存建议：
- Store at -20 degree C. Stable for 1 year.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Rabbit polyclonal antibodies are supplied in phosphate-buffered saline (PBS), 50% glycerol, 1mg/ml BSA, and 0.05% sodium azide.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Background: Cellular morphology, adhesion, and motility occur through dynamic reorganization of actin-based superstructures. Actinbinding proteins are critical for regulating actin polymerization and superstructure formation. The Arp2/3 complex is an actin polymerization-inducing complex that includes Arp2, Arp3, p41-Arc, p34-Arc, p21-Arc, p20-Arc, and p16-Arc. Several nucleation promoting factors, such as WASP and coronin, regulate the activity of the Arp2/3 complex. In addition, the Arp2/3 complex may be regulated by phosphorylation of specific subunits in the complex. Arp2 has two phosphosites, Thr-237 and Thr-238, that are evolutionarily conserved, and are phosphorylated along with Tyr-202 in response to growth factor stimulation. p41-Arc (Arpc1b) subunit Arpc1 has two isoforms in humans, Arpc1a and Arpc1b. PAK1 can bind and phosphorylate Thr-21 in Arpc1b leading to growth factor-stimulated cell motility. In addition, Arpc1b colocalizes with gamma- tubulin at centrosomes and stimulates Aurora A activity.
