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gamma-Catenin Phospho-Regulation
gamma-Catenin Phospho-Regulation
- 中文名称：
- gamma-Catenin Phospho-Regulation
- 英文名称：
- gamma-Catenin Phospho-Regulation
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA71572
- 规格：
- 1 Kit|2x1 Kit|3x1 Kit|4x1 Kit|5x1 Kit
- 保存建议：
- Store at -20°C. Do not aliquot. Stable for 1 year.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Supplied in phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Background: Plakoglobin (gamma-catenin) is a catenin family member identified as a component of desmosomes. gamma-Catenin has high homology to beta-catenin and, like beta-catenin, it can associate with the cadherins, E-cadherin and N-cadherin. One molecule of alpha-catenin and at least one molecule of beta-catenin and gamma-catenin simultaneously bind to a single cadherin molecule. A 19-amino acid sequence of desmoglein was found to be critical for binding of gamma-catenin. Similar catenin-binding domains found in cadherins, suggest a common mechanism for gamma-catenin localization to both adherens junctions and desmosomes. Phosphorylation of tyrosine residues (Tyr-133, Tyr-480, Tyr-550, Tyr-644) in gamma-catenin can modify its interactions with other proteins. Phosphorylation of Tyr-644 decreases gamma-catenin association with alpha-catenin, but increases binding to desmoplakin. Fer kinase can phosphorylate Tyr-550, which increases gamma-catenin binding to alpha-catenin. Thus, tyrosine phosphorylation may be important for regulation of gamma-catenin protein-protein interactions within desmosomal complexes.
