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IkBA recombinant protein
IkBA recombinant protein
- 中文名称：
- IkBA recombinant protein
- 英文名称：
- IkBA recombinant protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA72909
- 规格：
- 0.02 mg|0.1 mg|1 mg|2x1 mg|3x1 mg
- 保存建议：
- Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Shipping: Dry Ice.
- 货期：
- 6-8周
- 纯度：
- >90%
- 产品形式：
- 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Recombinant human IkBA (1-175) was expressed in E. coli cells using an N-terminal GST tag.
Scientific Background: Itheta degree Balpha is an inhibitor of the NFtheta degree B complex and inactivates the NFtheta degree B by trapping it in the cytoplasm (1). Phosphorylation of serine residues on the Itheta degree B protein by Itheta degree B kinases (IKKs) marks it for destruction via the ubiquitination pathway, thereby allowing the activation of the NFtheta degree B complex. Synthetic glucocorticoid such as dexamethasone display anti-inflammatory effects by inducing the increased synthesis of the Itheta degree B protein thereby inhibiting the activity of the NFtheta degree B complex. Overexpression of the Itheta degree Balpha gene in fibroblasts leads to inhibition of production of IL-6, TNF receptor, MMP-1, MMP-3 and MMP-13 (2).
Product Description: Recombinant human 1KappaBalpha(1-175) was expressed in E.coli cells using an N-terminal GST tag.
