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IRAK1 (catalytic domain), Active
IRAK1 (catalytic domain), Active
- 中文名称：
- IRAK1 (catalytic domain), Active
- 英文名称：
- IRAK1 (catalytic domain), Active
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA73158
- 规格：
- 0.01 mg|0.05 mg|0.5 mg|2x0.5 mg|3x0.5 mg
- 保存建议：
- Stability:
1 year at -70 degree C from date of shipment.
Storage & Shipping:
Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Shipping: Ships on Dry ice.
- 货期：
- 6-8周
- 纯度：
- >85%
- 产品形式：
- Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, and 25% glycerol.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Recombinant human IRAK1 (194-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is NM_001569.
IRAK1 encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. The exposure of HeLa cells or human embryonic kidney cells overexpressing IL1R to IL1 caused rapid association of IRAK with the IL1R complex and phosphorylation of IRAK (1). IRAK1 is partially responsible for IL1-induced upregulation of the transcription factor NFkappa B. IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus.
