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BIRC7, Active
BIRC7, Active
- 中文名称：
- BIRC7, Active
- 英文名称：
- BIRC7, Active
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA73283
- 规格：
- 0.02 mg|0.1 mg|1 mg|2x1 mg|3x1 mg
- 保存建议：
- Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant proteins stored in 50mM Tris-HCl, pH7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Recombinant full-length human BIRC7 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The BIRC7 gene accession number is BC014475.
Baculoviral IAP repeat-containing protein 7 (BIRC7) is a member of the newly discovered inhibitor of apoptosis proteins (IAPs) family whose activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase. Highly expressed in tumor tissues and inhibits tumor cell apoptosis through blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. BIRC7 expression in breast cancer correlated with the clinical stage and axillary lympHnode metastasis, and promotes breast cancer metastasis through the activation of AKT signaling and induction of EMT in breast cancer cells.
