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2019-nCoV Spike protein S1 (delta69-70 delta144 N501Y A570D D614G P681H)
2019-nCoV Spike protein S1 (delta69-70 delta144 N501Y A570D D614G P681H)
- 中文名称：
- 2019-nCoV Spike protein S1 (delta69-70 delta144 N501Y A570D D614G P681H)
- 英文名称：
- 2019-nCoV Spike protein S1 (delta69-70 delta144 N501Y A570D D614G P681H)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA73333
- 规格：
- 0.01 mg|0.02 mg|0.05 mg|0.1 mg|2x0.1 mg
- 保存建议：
- Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant protein stored in 50mM sodium phosphate, pH7.5, 300mM NaCl, 150mM imidazole.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Recombinant 2019-nCoV Spike protein S1 (delta69 -70 delta144 N501Y A570D D614G P681H)(16-685) was expressed in CHO cells using a C-terminal His-tag. The gene accession number is MN908947.
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remains the most rapidly spreading disease since 2020. The spike glycoprotein (S) of coronavirus, a type I transmembrane protein containing two subunits S1 and S2, facilitates viral genome entry into the host cells through the interaction with angiotensin-converting enzyme 2 (ACE2)(1). The current UK variant B.1.1.7 contains 9 out of 23 mutations in the Spike protein. Of the mutations found in the Spike protein of the UK variant, delta69-70 and D614G have been associated with higher viral infectivity. N501Y is known to increase affinity for ACE2 and P681H mutation found adjacent to the furin cleavage site possibly plays a role in spike protein processing (2,3).
